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Icostm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Icostm1Flv
Name: inducible T cell co-stimulator; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2683635
Synonyms: ICOS-
Gene: Icos  Location: Chr1:60977927-61000320 bp, + strand  Genetic Position: Chr1, 30.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87123
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe three exons for all of the amino acid coding sequence except the leader peptide were replaced with a PGK-neomycin resistance cassette. Absence of protein product was demonstrated immunologically. (J:87123)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Icos Mutation:  20 strains or lines available
References
Original:  J:87123 Dong C, et al., ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 2001 Jan 4;409(6816):97-101
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory