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Icosltm1Cdon
Targeted Allele Detail
Nomenclature
Symbol: Icosltm1Cdon
Name: icos ligand; targeted mutation 1, Chen Dong
MGI ID: MGI:2683493
Synonyms: B7h-
Gene: Icosl  Location: Chr10:78069368-78079525 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86697
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsTwo loxP sites were inserted so as to flank the two exons encoding the extracellular Ig-like domains as well as an FRT enclosed neomycin resistance gene (Icosltm2Cdon. These two exons and the neomycin gene were subsequently removed by crossing F1 mice with a cytomegalovirus-cre transgenic mouse. Absence of protein product was confirmed immunologically. (J:86697)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icosl Mutation:  6 strains or lines available
References
Original:  J:86697 Nurieva RI, et al., B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14163-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory