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Gabrr1tm1Llu
Targeted Allele Detail
Nomenclature
Symbol: Gabrr1tm1Llu
Name: gamma-aminobutyric acid (GABA) C receptor, subunit rho 1; targeted mutation 1, Luo Lu
MGI ID: MGI:2683490
Synonyms: rho1-
Gene: Gabrr1  Location: Chr4:33132556-33163606 bp, + strand  Genetic Position: Chr4, 14.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86721
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.5 kb genomic fragment encompassing a portion of the promoter region and exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of RNA from spinal cord lumbar segments and retinal tissue. (J:86721)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrr1 Mutation:  23 strains or lines available
References
Original:  J:86721 Zheng W, et al., Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. J Biol Chem. 2003 Nov 28;278(48):48321-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory