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Sncgtm1Vlb
Targeted Allele Detail
Nomenclature
Symbol: Sncgtm1Vlb
Name: synuclein, gamma; targeted mutation 1, Vladimir L Buchman
MGI ID: MGI:2683142
Synonyms: TgHSNCGtm1VLB
Gene: Sncg  Location: Chr14:34092231-34096626 bp, - strand  Genetic Position: Chr14, 20.81 cM, cytoband B-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86439
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from various tissues. Western blot analysis of total spinal cord protein indicated an absence of protein in homozygous mutant mice. (J:86439)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sncg Mutation:  13 strains or lines available
References
Original:  J:86439 Ninkina N, et al., Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene. Mol Cell Biol. 2003 Nov;23(22):8233-45
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory