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Targeted Allele Detail
Symbol: Cdc25btm1Pjd
Name: cell division cycle 25B; targeted mutation 1, Peter J Donovan
MGI ID: MGI:2682953
Synonyms: Cdc25b-
Gene: Cdc25b  Location: Chr2:131186949-131198497 bp, + strand  Genetic Position: Chr2, 63.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:87011
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 4.0 kb region encoding the phosphatase box was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of homozygous mutant MEF extracts using an N-terminal antibody. (J:87011)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc25b Mutation:  19 strains or lines available
Original:  J:87011 Lincoln AJ, et al., Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet. 2002 Apr;30(4):446-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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