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Hmmrtm1Baa
Targeted Allele Detail
Nomenclature
Symbol: Hmmrtm1Baa
Name: hyaluronan mediated motility receptor (RHAMM); targeted mutation 1, Benjamin A Alman
MGI ID: MGI:2682898
Synonyms: Rhamm-
Gene: Hmmr  Location: Chr11:40701395-40733422 bp, - strand  Genetic Position: Chr11, 24.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86065
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment encompassing exons 8 through 16 was replaced with a Hprt minigene. Full length transcript was undetected by RT-PCR analysis of homozygous mutant spleen tissue. Analysis of homozygous mutant MEFs identified aberrant transcript in which exon 7 had spliced to exon 17. Sequence analysis indicated a frameshift mutation at the aberrant splice junction, affecting downstream sequence encoding the HA-binding region. Western blot analyses of homozygous spleen tissue and MEFs did not detect protein corresponding with the mutant transcript. (J:86065)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmmr Mutation:  17 strains or lines available
References
Original:  J:86065 Tolg C, et al., Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Oncogene. 2003 Oct 9;22(44):6873-82
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory