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Slc6a5tm1Betz
Targeted Allele Detail
Nomenclature
Symbol: Slc6a5tm1Betz
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5; targeted mutation 1, Heinrich Betz
MGI ID: MGI:2682554
Synonyms: GlyT2-/-
Gene: Slc6a5  Location: Chr7:49559894-49613604 bp, + strand  Genetic Position: Chr7, 31.71 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86625
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.1 kb genomic fragment encompassing the exons encoding the fourth transmembrane domain was replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by RT-PCR or Western blot analyses of homozygous mutant brain stem tissue. The absence of protein was also verified in fractions obtained from mutant spinal cord extracts. (J:86625)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a5 Mutation:  43 strains or lines available
References
Original:  J:86625 Gomeza J, et al., Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron. 2003 Nov 13;40(4):797-806
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory