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Pdgfrbtm10Sor
Targeted Allele Detail
Nomenclature
Symbol: Pdgfrbtm10Sor
Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 10, Philippe Soriano
MGI ID: MGI:2682393
Synonyms: BetaT
Gene: Pdgfrb  Location: Chr18:61045150-61085061 bp, + strand  Genetic Position: Chr18, 34.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86542
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Nucleotide substitutions
 
Mutation detailsA frameshift mutation was generated at codon 780, resulting in a nonsense mutation at 801. This stop codon is 11 residues downstream of the RasGAP binding site and precludes the translation of the SHP-2 and PLC-gamma binding sites. (J:86542)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:  16 strains or lines available
References
Original:  J:86542 Tallquist MD, et al., Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol. 2003 Nov;1(2):288-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory