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Targeted Allele Detail
Symbol: Prnptm2Rcm
Name: prion protein; targeted mutation 2, Richard C Moore
MGI ID: MGI:2682351
Synonyms: Rcm0
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Germline Transmission:  Earliest citation of germline transmission: J:42407
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment encompassing the entire coding region contained within exon 3 as well as approximately 1 kb of sequence 5' to exon 3 was replaced with a PGK-HPRT cassette. The deleted upstream sequence included the exon 3 splice acceptor site. RT-PCR analysis of RNA obtained from homozygous mutant brain tissue showed increased levels of chimeric transcript consisting of Prnp and Prnd sequence relative to wild-type samples. (J:42407)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  89 strains or lines available
Original:  J:42407 Moore RC, et al., Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol. 1999 Oct 1;292(4):797-817
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory