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Targeted Allele Detail
Symbol: Prnptm1(PRNP)Tkit
Name: prion protein; targeted mutation 1, Tetsuyuki Kitamoto
MGI ID: MGI:2681980
Synonyms: Hu-Ki, Ki-ChM
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Germline Transmission:  Earliest citation of germline transmission: J:33412
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Prnptm1(PRNP)Tkit expresses 1 gene
Mutation detailsThe majority of the endogenous mouse gene was replaced with mutant human PRNP sequence. The human sequence contained a nonsense mutation at codon 145. 3' mouse sequence remained downstream of the inserted human sequence. (J:33412, J:86603)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  84 strains or lines available
Original:  J:33412 Kitamoto T, et al., Humanized prion protein knock-in by Cre-induced site-specific recombination in the mouse. Biochem Biophys Res Commun. 1996 May 24;222(3):742-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory