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Tas1r2tm1Csz
Targeted Allele Detail
Nomenclature
Symbol: Tas1r2tm1Csz
Name: taste receptor, type 1, member 2; targeted mutation 1, Charles S Zuker
MGI ID: MGI:2681886
Synonyms: T1R2-
Gene: Tas1r2  Location: Chr4:139653538-139670280 bp, + strand  Genetic Position: Chr4, 70.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86474
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 5 and 6 were replaced with a PGK-neo cassette inserted by homologous recombination. Protein was undetected by in situ hybridization of homozygous mutant taste bud sections. (J:86474)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tas1r2 Mutation:  22 strains or lines available
Notes
Results reported in J:86474 were in conjunction with a Tas1r3Sac-b "taster" allele, however qualitatively similar data was obtained in conjunction with a Tas1r3sac-d "non-taster" allele.
References
Original:  J:86474 Zhao GQ, et al., The receptors for mammalian sweet and umami taste. Cell. 2003 Oct 31;115(3):255-66
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory