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Irx2tm1Hui
Targeted Allele Detail
Summary
Symbol: Irx2tm1Hui
Name: Iroquois homeobox 2; targeted mutation 1, Chi-Chung Hui
MGI ID: MGI:2681629
Synonyms: Irx2LacZ/LacZ (-)
Gene: Irx2  Location: Chr13:72776939-72782317 bp, + strand  Genetic Position: Chr13, 39.23 cM
Alliance: Irx2tm1Hui page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86477
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 1 and intron 1 were replaced by an IRES-lacZ reporter gene followed by a floxed PGK-neo cassete. PGK-neo was excised in vivo by crossing carriers with NLS-Cre transgenic mice which express cre ubiquitously. Western blot analysis indicated that the protein product was not produced. (J:86477)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irx2 Mutation:  23 strains or lines available
References
Original:  J:86477 Lebel M, et al., The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Mol Cell Biol. 2003 Nov;23(22):8216-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory