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Gcnt1tm2Jxm
Targeted Allele Detail
Nomenclature
Symbol: Gcnt1tm2Jxm
Name: glucosaminyl (N-acetyl) transferase 1, core 2; targeted mutation 2, Jamey Marth
MGI ID: MGI:2681555
Synonyms: C2 GlcNAcTF
Gene: Gcnt1  Location: Chr19:17303505-17350208 bp, - strand  Genetic Position: Chr19, 12.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86387
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe single protein coding exon was flanked upstream by a loxP site and downstream by a floxed neomycin resistance cassette. Transient Cre expression in correctly targeted cells resulted in removal of only the neomycin cassette in some ES cells. (J:86387)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcnt1 Mutation:  23 strains or lines available
References
Original:  J:86387 Ellies LG, et al., Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity. 1998 Dec;9(6):881-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory