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Targeted Allele Detail
Symbol: Gcnt1tm1Jxm
Name: glucosaminyl (N-acetyl) transferase 1, core 2; targeted mutation 1, Jamey Marth
MGI ID: MGI:2681554
Synonyms: C2GlcNAcTdelta, C2GlcNAcT-I-, C2GlcNAcT-Inull, C2GnT1-, Core2GlcNAcT
Gene: Gcnt1  Location: Chr19:17303505-17350208 bp, - strand  Genetic Position: Chr19, 12.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:86387
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe single protein coding exon was flanked upstream by a loxP site and downstream by a floxed neomycin resistance cassette. Transient Cre expression in correctly targeted cells resulted in removal of both the coding exon and the neomycin cassette. Enzyme activity was absent in spleen, bone marrow, and kidney tissue of homozygotes. (J:86387)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcnt1 Mutation:  23 strains or lines available
Original:  J:86387 Ellies LG, et al., Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity. 1998 Dec;9(6):881-90
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory