Fbln5^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Fbln5^tm1Eno
• Name: fibulin 5; targeted mutation 1, Eric N Olson
• MGI ID: MGI:2681517
• Synonyms: C18-6, fbln5-, fibulin-5-
• Gene: Fbln5 Location: Chr12:101712824-101785314 bp, - strand Genetic Position: Chr12, 51.29 cM, cytoband F1
• Alliance: Fbln5^tm1Eno page

Vascular remodeling in Fbln5^tm1Eno/Fbln5^tm1Eno mice after 28 days of ligation

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86754
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing lacZ and neo was inserted at the first start codon, located in exon 1a. Deleted sequence included the coding region of exon 1a, intron 1, and the 5' untranslated region of exon 1b. The downstream start codon, located in exon 1b, was left intact. Protein was undetected by Western blot analysis of skin fibroblasts and vascular smooth muscle cells obtained from homozygous mutant mice. (J:86754)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbln5 Mutation: 35 strains or lines available

References

• Original: J:86754 Yanagisawa H, et al., Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature. 2002 Jan 10;415(6868):168-71
• All: 19 reference(s)