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Targeted Allele Detail
Symbol: Camkk2tm1Kpg
Name: calcium/calmodulin-dependent protein kinase kinase 2, beta; targeted mutation 1, K Peter Giese
MGI ID: MGI:2681319
Gene: Camkk2  Location: Chr5:122731170-122779409 bp, - strand  Genetic Position: Chr5, 62.55 cM
Germline Transmission:  Earliest citation of germline transmission: J:86370
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 5 was removed via cre mediated recombination of a single loxP site in intron 4 and the 3' loxP site of a floxed neo cassette in intron 5. The deletion of exon 5 results in the removal of sequence encoding part of the catalytic domain common to all CaM kinase kinase beta isoforms and putatively generates a frameshift mutation that leads to a premature stop codon. Protein was undetected in the forebrain and cerebellum of homozygous mutant mice by homologous recombination. (J:86370)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Camkk2 Mutation:  23 strains or lines available
Original:  J:86370 Peters M, et al., Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory. J Neurosci. 2003 Oct 29;23(30):9752-60
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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