About   Help   FAQ
Mmp8tm1Otin
Targeted Allele Detail
Nomenclature
Symbol: Mmp8tm1Otin
Name: matrix metallopeptidase 8; targeted mutation 1, Carlos Lopez-Otin
MGI ID: MGI:2681103
Synonyms: collagenase-2 deficient, Mmp8-, MMP-8 KO, Mmp8tm1Lotn
Gene: Mmp8  Location: Chr9:7558456-7568485 bp, + strand  Genetic Position: Chr9, 2.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86393
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 2 and all of exons 3 and 4 were replaced with a PGK-neomycin gene. Lack of protein product verified by immunofluorescence analysis blood neutrophils and by Western blot analysis. (J:86393)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mmp8 Mutation:  3 strains or lines available
References
Original:  J:86393 Balbin M, et al., Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet. 2003 Nov;35(3):252-7
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/15/2019
MGI 6.14
The Jackson Laboratory