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QTL Variant Detail
QTL variant: Eila2C57BL/6J
Name: ethanol induced locomotor activity 2; C57BL/6J
MGI ID: MGI:2680938
QTL: Eila2  Location: Chr6:48726556-125356785 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 37.96 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased ethanol induced activation of locomotor activity compared to C3H/HeJ. (J:85747)
Inheritance:    Other (see notes)
View phenotypes and curated references for all genotypes (concatenated display).
Eila2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers


Genome scan was performed on a 1204 (C57BL/6J x C3H/HeJ)F2 animals, 794 (C57BL/6J x C3H/HeJ)F1 x C57BL/6J backcross animals, and 680 (C57BL/6J x C3H/HeJ)F1 x C3H/HeJ backcross animals to identify QTLs associated with ethanol-induced activation of locomotor activity. Parental strain C57BL/6J exhibits little or no activation of locomotor activity when administered ethanol solution whereas parental strain C3H/HeJ exhibits increased locomotor activity when administered ethanol solution. 79 microsatellite markers at an average spacing of 17 cM were used in the genome scan.

A female-specific locus associated with ethanol-induced locomotor activity, Eila1, mapped to 100 cM on mouse Chromosome 1 with LOD=6.4 at D1Mit403. C57BL/6J-derived alleles confer increased locomotor activation at Eila1 with recessive inheritance. The QTL range of Eila1 spans 84 cM - telomere and is flanked by markers D1Mit15 and D1Mit26. Eila1 accounts for 3-5% of the phenotypic variance.

Eila2 mapped to 47 cM on mouse Chromosome 6 with LOD=9.8-10.4 at D6Mit9. C57BL/6J-derived alleles confer additively inherited increased locomotor activation at this locus. The QTL range of Eila1 spans 34 cM - 58 cM and is flanked by markers D6Mit74 and D6Mit254. Eila2 accounts for 9-10% of the phenotypic variance.

Eila3 mapped to 28 cM on mouse Chromosome 15 with LOD=7.3-8.8 at D15Mit111. C3H/HeJ-derived alleles confer additively-inherited increased locomotor activation at this locus. The QTL range of Eila3 spans 18 cM - 44 cM. Eila3 accounts for 9% ofthe phenotypic variance.

Original:  J:85747 Downing C, et al., Genetic analysis of the psychomotor stimulant effect of ethanol. Genes Brain Behav. 2003 Jun;2(3):140-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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