Havcr2^tm1Tbs
Targeted Allele Detail

Summary

• Symbol: Havcr2^tm1Tbs
• Name: hepatitis A virus cellular receptor 2; targeted mutation 1, Terry B Strom
• MGI ID: MGI:2680763
• Gene: Havcr2 Location: Chr11:46345762-46372082 bp, + strand Genetic Position: Chr11, 27.9 cM
• Alliance: Havcr2^tm1Tbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86260
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.4 kb genomic fragment, including all of exon 1 and a portion of exon 2 was replaced with a neo cassette inserted by homologous recombination. Flow cytometry of homozygous null lymphocytes indicated an absence of normal protein. (J:86260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Havcr2 Mutation: 32 strains or lines available

References

• Original: J:86260 Sanchez-Fueyo A, et al., Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov;4(11):1093-101
• All: 10 reference(s)