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Havcr2tm1Tbs
Targeted Allele Detail
Nomenclature
Symbol: Havcr2tm1Tbs
Name: hepatitis A virus cellular receptor 2; targeted mutation 1, Terry B Strom
MGI ID: MGI:2680763
Gene: Havcr2  Location: Chr11:46454935-46481255 bp, + strand  Genetic Position: Chr11, 27.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86260
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5.4 kb genomic fragment, including all of exon 1 and a portion of exon 2 was replaced with a neo cassette inserted by homologous recombination. Flow cytometry of homozygous null lymphocytes indicated an absence of normal protein. (J:86260)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Havcr2 Mutation:  9 strains or lines available
References
Original:  J:86260 Sanchez-Fueyo A, et al., Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov;4(11):1093-101
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory