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Akp3tm1Jlm
Targeted Allele Detail
Nomenclature
Symbol: Akp3tm1Jlm
Name: alkaline phosphatase 3, intestine, not Mn requiring; targeted mutation 1, Jose Luis Millan
MGI ID: MGI:2680530
Synonyms: IAP-
Gene: Akp3  Location: Chr1:87124973-87127912 bp, + strand  Genetic Position: Chr1, 44.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86263
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 6 were replaced with a neomycin resistance gene. Disruption of gene expression was confirmed by RT-PCR, Northern blot, Western blot, and immunohistochemistry.. (J:86263)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akp3 Mutation:  26 strains or lines available
References
Original:  J:86263 Narisawa S, et al., Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol Cell Biol. 2003 Nov;23(21):7525-30
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory