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Mplhlb219
Chemically induced Allele Detail
Nomenclature
Symbol: Mplhlb219
Name: myeloproliferative leukemia virus oncogene; heart, lung and blood, 219
MGI ID: MGI:2680465
Gene: Mpl  Location: Chr4:118299612-118314710 bp, - strand  Genetic Position: Chr4, 54.61 cM, cytoband D
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsDNA sequencing of exons from genomic DNA revealed a single point mutation in the Mpl gene at codon 40. The mutation is a T-to-C transition yielding an amino acid change from a conserved cysteine to an arginine. (J:146577)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mpl Mutation:  30 strains or lines available
References
Original:  J:82961 JAX National Heart, Lung and Blood Program for Genomic Applications (PGA), Heritable mouse mutants from the JAX NHLBI ENU Mutagenesis Program. MGI Direct Data Submission. 2003-10;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory