Erbb4^tm1Fej
Targeted Allele Detail

Summary

• Symbol: Erbb4^tm1Fej
• Name: erb-b2 receptor tyrosine kinase 4; targeted mutation 1, Frank E Jones
• MGI ID: MGI:2680217
• Synonyms: erbB4^F, Erbb4^Flox
• Gene: Erbb4 Location: Chr1:68071345-69147218 bp, - strand Genetic Position: Chr1, 33.8 cM
• Alliance: Erbb4^tm1Fej page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86319
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1 and another in intron 2, thus flanking exon2. In addition, a neomycin resistance gene flanked by frt sites was inserted downstream of exon 2. (J:86319)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erbb4 Mutation: 87 strains or lines available

References

• Original: J:86319 Long W, et al., Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development. 2003 Nov;130(21):5257-68
• All: 51 reference(s)