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Erbb4tm1Fej
Targeted Allele Detail
Nomenclature
Symbol: Erbb4tm1Fej
Name: erb-b2 receptor tyrosine kinase 4; targeted mutation 1, Frank E Jones
MGI ID: MGI:2680217
Synonyms: erbB4F, Erbb4Flox
Gene: Erbb4  Location: Chr1:68032186-69108059 bp, - strand  Genetic Position: Chr1, 33.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86319
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in intron 1 and another in intron 2, thus flanking exon2. In addition, a neomycin resistance gene flanked by frt sites was inserted downstream of exon 2. (J:86319)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Erbb4 Mutation:  54 strains or lines available
References
Original:  J:86319 Long W, et al., Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development. 2003 Nov;130(21):5257-68
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory