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Prkcetm1Ltg
Targeted Allele Detail
Nomenclature
Symbol: Prkcetm1Ltg
Name: protein kinase C, epsilon; targeted mutation 1, Michael Leitges
MGI ID: MGI:2680163
Synonyms: PKC-epsilon-
Gene: Prkce  Location: Chr17:86167785-86657919 bp, + strand  Genetic Position: Chr17, 56.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86056
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ-neomycin cassette was inserted in exon 1 interrupting the initiation codon. Western blot analysis demonstrated the absence of gene product in homozygotes and reduced protein levels in heterozygotes. (J:86056)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkce Mutation:  6 strains or lines available
References
Original:  J:86056 Wheeler DL, et al., Protein Kinase Cepsilon Is Linked to 12-O-tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor-alpha Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase Cepsilon Transgenic Mice. Cancer Res. 2003 Oct 1;63(19):6547-55
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory