Prkce^tm1Ltg
Targeted Allele Detail

Nomenclature

• Symbol: Prkce^tm1Ltg
• Name: protein kinase C, epsilon; targeted mutation 1, Michael Leitges
• MGI ID: MGI:2680163
• Synonyms: PKC-epsilon-
• Gene: Prkce Location: Chr17:86167785-86657919 bp, + strand Genetic Position: Chr17, 56.74 cM

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86056
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-neomycin cassette was inserted in exon 1 interrupting the initiation codon. Western blot analysis demonstrated the absence of gene product in homozygotes and reduced protein levels in heterozygotes. (J:86056)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkce Mutation: 6 strains or lines available

References

• Original: J:86056 Wheeler DL, et al., Protein Kinase Cepsilon Is Linked to 12-O-tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor-alpha Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase Cepsilon Transgenic Mice. Cancer Res. 2003 Oct 1;63(19):6547-55
• All: 13 reference(s)