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Targeted Allele Detail
Symbol: Slc12a6tm1Tjj
Name: solute carrier family 12, member 6; targeted mutation 1, Thomas J Jentsch
MGI ID: MGI:2680042
Gene: Slc12a6  Location: Chr2:112265825-112363163 bp, + strand  Genetic Position: Chr2, 56.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:86183
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA cassette containing lacZ and neo replaced a 2.2 kb genomic fragment encompassing 95 bp of exon 3 and all of exon 4. While normal protein was undetected by Western blot analysis of various tissues obtained from homozygous mutant mice, expression of a hybrid protein consisting of the endogenous N-terminal fused to lacZ was detected. (J:86183)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc12a6 Mutation:  96 strains or lines available
Original:  J:86183 Boettger T, et al., Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO J. 2003 Oct 15;22(20):5422-34
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory