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Targeted Allele Detail
Symbol: Cd44tm1Ugu
Name: CD44 antigen; targeted mutation 1, Ursula Gunthert
MGI ID: MGI:2679704
Synonyms: CD44v7-
Gene: Cd44  Location: Chr2:102811141-102901665 bp, - strand  Genetic Position: Chr2, 54.13 cM
Germline Transmission:  Earliest citation of germline transmission: J:62867
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted 3' of exon v6 while a neomycin resistance cassette with a 5' loxP site was inserted 5' of exon v6. During insertion, 1.6 kb of sequence was lost in the exon v7 region leading to deficient expression of this variant in homozygous mutant mice. (J:62867)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Cd44 Mutation:  32 strains or lines available
Original:  J:62867 Wittig BM, et al., Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med. 2000 Jun 19;191(12):2053-64
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory