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Cd44tm1Ugu
Targeted Allele Detail
Nomenclature
Symbol: Cd44tm1Ugu
Name: CD44 antigen; targeted mutation 1, Ursula Gunthert
MGI ID: MGI:2679704
Synonyms: CD44v7-
Gene: Cd44  Location: Chr2:102811141-102901625 bp, - strand  Genetic Position: Chr2, 54.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62867
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted 3' of exon v6 while a neomycin resistance cassette with a 5' loxP site was inserted 5' of exon v6. During insertion, 1.6 kb of sequence was lost in the exon v7 region leading to deficient expression of this variant in homozygous mutant mice. (J:62867)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Cd44 Mutation:  45 strains or lines available
References
Original:  J:62867 Wittig BM, et al., Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med. 2000 Jun 19;191(12):2053-64
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory