Cd44^tm1Ugu
Targeted Allele Detail

Summary

• Symbol: Cd44^tm1Ugu
• Name: CD44 antigen; targeted mutation 1, Ursula Gunthert
• MGI ID: MGI:2679704
• Synonyms: CD44v7-
• Gene: Cd44 Location: Chr2:102641486-102732010 bp, - strand Genetic Position: Chr2, 54.13 cM
• Alliance: Cd44^tm1Ugu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62867
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 3' of exon v6 while a neomycin resistance cassette with a 5' loxP site was inserted 5' of exon v6. During insertion, 1.6 kb of sequence was lost in the exon v7 region leading to deficient expression of this variant in homozygous mutant mice. (J:62867)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Cd44 Mutation: 67 strains or lines available

References

• Original: J:62867 Wittig BM, et al., Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med. 2000 Jun 19;191(12):2053-64
• All: 10 reference(s)