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Fastm1Vbo
Targeted Allele Detail
Nomenclature
Symbol: Fastm1Vbo
Name: Fas (TNF receptor superfamily member 6); targeted mutation 1, Harald von Boehmer
MGI ID: MGI:2679555
Synonyms: fasfl
Gene: Fas  Location: Chr19:34290659-34327770 bp, + strand  Genetic Position: Chr19, 29.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85985
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exon 9, the death domain encoding exon, was flanked by single loxP sites. (J:85985)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fas Mutation:  37 strains or lines available
References
Original:  J:85985 Apostolou I, et al., Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med. 2003 Oct 6;198(7):1103-6
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory