About   Help   FAQ
Targeted Allele Detail
Symbol: Acacbtm1Sjw
Name: acetyl-Coenzyme A carboxylase beta; targeted mutation 1, Salih J Wakil
MGI ID: MGI:2679547
Synonyms: Acc2-, Acc2tm1AE
Gene: Acacb  Location: Chr5:114146535-114250761 bp, + strand  Genetic Position: Chr5, 55.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:68427
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon encoding the biotin binding motif and flanking genomic sequence was replaced by an HPRT expression cassette by homologous recombination. Northern blot analysis on RNA derived from skeletal muscle demonstrated that no detectable transcript was expressed from this allele in homozygous mice. Western blot analysis on extracts of various tissues confirmed that no detectable protein was present in homozygous mice. (J:68427)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acacb Mutation:  14 strains or lines available
Original:  J:68427 Abu-Elheiga L, et al., Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001 Mar 30;291(5513):2613-6
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory