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Nr1h4tm1Kok
Targeted Allele Detail
Nomenclature
Symbol: Nr1h4tm1Kok
Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1, Tineke Kok
MGI ID: MGI:2679472
Synonyms: Fxr-
Gene: Nr1h4  Location: Chr10:89454234-89533585 bp, - strand  Genetic Position: Chr10, 44.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86154
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by the insertion of a neomycin selection cassette. Transcript was undetected by Northern blot analysis of hepatic RNA obtained from homozygous mutant mice. (J:86154)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h4 Mutation:  10 strains or lines available
References
Original:  J:86154 Kok T, et al., Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem. 2003 Oct 24;278(43):41930-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory