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Fostm7Wag
Targeted Allele Detail
Nomenclature
Symbol: Fostm7Wag
Name: FBJ osteosarcoma oncogene; targeted mutation 7, Erwin F Wagner
MGI ID: MGI:2679338
Synonyms: c-fosf, Fostm1Pga
Gene: Fos  Location: Chr12:85473901-85477269 bp, + strand  Genetic Position: Chr12, 39.7 cM
Reduced tumor growth in Fostm7Wag/Fostm7Wag Tg(Cd4-cre)1Cwi/0 mice following carcinoma cell inoculation

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85928
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in the first intron and a PGK neomycine cassette flanked by flp sites was inserted along with a second loxP site downstream of the polyadenylation signal. Still further downstream, a splice acceptor was placed just 5' to an EGFP gene insert. The PGK neo construct was deleted in vivo using flip recombinase transgenic mice. (J:85928)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fos Mutation:  28 strains or lines available
References
Original:  J:85928 Fleischmann A, et al., Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci. 2003 Oct 8;23(27):9116-22
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory