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Pias2Gt(pT1Betageo)1Ruiz
Gene trapped Allele Detail
Nomenclature
Symbol: Pias2Gt(pT1Betageo)1Ruiz
Name: protein inhibitor of activated STAT 2; gene trap 1, Patricia Ruiz
MGI ID: MGI:2678428
Gene: Pias2  Location: Chr18:77065208-77155708 bp, + strand  Genetic Position: Chr18, 52.07 cM
Mutation
origin
Mutant Cell Line:  W027F01 (GGTC)
Germline Transmission:  Earliest citation of germline transmission: J:85162
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pT1betageo
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a gene trap vector containing a splice acceptor site followed by Beta-geo and a polyadenylation signal. (J:85162)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pias2 Mutation:  65 strains or lines available
Notes
Information submitted to the NCBI Genome Survey Sequences Database (dbGSS) by the German Genetrap Consortium (GGTC) for gene trap cell line W027F01 gives R1 as the ES cell line used to create this allele. The original publication reporting large scale production of gene trap clones using four gene trap vectors says that ES cell-derived chimeras were produced using three ES cell lines (E14.1 (129P2/OlaHsd), R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+), TBV2 (129S2/SvPas)). GGTC records currently say that E14 ES cells were used to generate this allele. Chimeric mice were subsquently bred to C57BL/6 females.
References
Original:  J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory