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Gene trapped Allele Detail
Symbol: Spry4Gt(pT1ATGBetageo)1Ruiz
Name: sprouty RTK signaling antagonist 4; gene trap 1, Patricia Ruiz
MGI ID: MGI:2678385
Gene: Spry4  Location: Chr18:38586247-38601347 bp, - strand  Genetic Position: Chr18, 20.5 cM
Mutant Cell Line:  A006B04
Germline Transmission:  Earliest citation of germline transmission: J:85162
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pT1ATGbetageo
Mutation detailsThe endogenous locus was disrupted by the insertion of a gene trap vector containing a splice acceptor site followed by Beta-geo and a polyadenylation signal. (J:85162)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spry4 Mutation:  23 strains or lines available
Information submitted to the NCBI Genome Survey Sequences Database (dbGSS) by the German Genetrap Consortium (GGTC) for gene trap cell line A006B04 gives R1 as the ES cell line used to create this allele. The original publication reporting large scale production of gene trap clones using four gene trap vectors says that ES cell-derived chimeras were produced using three ES cell lines (E14.1 (129P2/OlaHsd), R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+), TBV2 (129S2/SvPas)). GGTC records currently say that R1 ES cells were used to generate this allele. Chimeric mice were subsquently bred to C57BL/6 females.
Original:  J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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