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Targeted Allele Detail
Symbol: Cops3tm2Jrl
Name: COP9 signalosome subunit 3; targeted mutation 2, James R Lupski
MGI ID: MGI:2678262
Synonyms: Csn3-, Csn33'm
Gene: Cops3  Location: Chr11:59817795-59839838 bp, - strand  Genetic Position: Chr11, 37.8 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:85760
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA 3'HPRT minigene segment along with a puromycin resistance gene was inserted after exon 6 and was followed by a duplication of exons 3-6 along with about 10kb of vector sequence. No protein product could be identified in homozygous mice by Western blot analysis. (J:85760)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cops3 Mutation:  21 strains or lines available
Original:  J:85760 Yan J, et al., COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol. 2003 Oct;23(19):6798-808
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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