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Cara2C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Cara2C57BL/6J
Name: carcass ash in high growth mice 2; C57BL/6J
MGI ID: MGI:2678054
QTL: Cara2  Location: unknown  Genetic Position: Chr11, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased carcass ash weight compared to CAST/EiJ. (J:68441)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
Cara2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68441

Authors indicated that enhanced growth rate in C57BL/6J-Cish2hg/Cish2hg mice may be modulated by other genes associated with growth. 1132 F2 mice from a cross between (C57BL/6J-Cish2hg/Cish2hg X CAST/EiJ)F1's yielded 274 +/+ , 596 hg/+ and 262 hg/hg mice with the hg/hg used in a genome wide scan to find QTLs associated with growth rates. A total of 15 QTLs were mapped. QTLs for total weight gain (wg1 - wg4) mapped to mouse Chromosomes 2, 8, and 11, with wg1 and wg2 mapping to mouse chromosome 2.QTLS for total carcass protein (Carp1-Carp3) mapped to Chromosomes 2, 11 and 17. QTLs for total carcass ash weight (Cara1-Cara3) mapped to mouse Chromosomes 2, 11 and 17. QTLs for percent carcass fat (Carf1 and Carf2) mapped to mouse Chromosomes 5 and 9 and QTLS for femur length (Feml1-Feml3) mapped to mouse chromosomes 2, 9, and 17.

References
Original:  J:68441 Corva PM, et al., Quantitative trait loci affecting growth in high growth (hg) mice. Mamm Genome. 2001 Apr;12(4):284-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory