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Apctm2Tno
Targeted Allele Detail
Nomenclature
Symbol: Apctm2Tno
Name: APC, WNT signaling pathway regulator; targeted mutation 2, Tetsuo Noda
MGI ID: MGI:2678005
Synonyms: Apc1309, APC1309, APC 1309, Apcdelta1309
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47857
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA frameshift mutation was introduced at codon 1309 via homolgous recombination, a most common germline mutation for human families susceptible to familial adenomatous polyposis coli (FAP). (J:47857)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  58 strains or lines available
References
Original:  J:47857 Quesada CF, et al., Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice. Jpn J Cancer Res. 1998 Apr;89(4):392-6
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory