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Mafbtm1Mhs
Targeted Allele Detail
Nomenclature
Symbol: Mafbtm1Mhs
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian); targeted mutation 1, Michael H Sieweke
MGI ID: MGI:2677917
Synonyms: Mafb-, MafBGFP
Gene: Mafb  Location: Chr2:160363703-160367065 bp, - strand  Genetic Position: Chr2, 80.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85746
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a cassette containing GFP and neoR. Protein was undetected by Western blot analysis of macrophages obtained from homozygous mutant mice. (J:85746)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mafb Mutation:  10 strains or lines available
References
Original:  J:85746 Blanchi B, et al., MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth. Nat Neurosci. 2003 Oct;6(10):1091-100
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory