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Targeted Allele Detail
Symbol: Sftpbtm1Jaw
Name: surfactant associated protein B; targeted mutation 1, Jeffrey A Whitsett
MGI ID: MGI:2677852
Synonyms: SP-B-
Gene: Sftpb  Location: Chr6:72304610-72314371 bp, + strand  Genetic Position: Chr6, 32.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:28289
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted in the 5' region of the endogenous gene by homologous recombination. Neither transcript nor protein was detected in homozygous mutant mice. (J:28289)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sftpb Mutation:  0 strains or lines available
Original:  J:28289 Clark JC, et al., Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7794-8
All:  14 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory