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Terf1tm1Tdl
Targeted Allele Detail
Nomenclature
Symbol: Terf1tm1Tdl
Name: telomeric repeat binding factor 1; targeted mutation 1, Titia de Lange
MGI ID: MGI:2677837
Synonyms: Terfex1delta
Gene: Terf1  Location: Chr1:15805646-15844052 bp, + strand  Genetic Position: Chr1, 4.88 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85440
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced by a neomycin resistance gene. Northern blot analysis of RNA purified from heterozygotes indicated only about half of the normal amount of mRNA transcript was present. No truncated mRNA species were observed. (J:85440)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Terf1 Mutation:  23 strains or lines available
References
Original:  J:85440 Karlseder J, et al., Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol. 2003 Sep;23(18):6533-41
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory