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Ncor1tm1Rsd
Targeted Allele Detail
Nomenclature
Symbol: Ncor1tm1Rsd
Name: nuclear receptor co-repressor 1; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:2677822
Synonyms: N-CoR -
Gene: Ncor1  Location: Chr11:62316426-62458541 bp, - strand  Genetic Position: Chr11, 38.08 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65417
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a 3 kb genomic fragment containing the coding sequences for the Sin3 interaction domain. Western blot analysis on lysates derived from MEFs of homozygous mice demonstrated that no detectable protein was produced from this allele. (J:65417)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncor1 Mutation:  336 strains or lines available
References
Original:  J:65417 Jepsen K, et al., Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000 Sep 15;102(6):753-63
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory