Ncor1^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Ncor1^tm1Rsd
• Name: nuclear receptor co-repressor 1; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:2677822
• Synonyms: N-CoR -
• Gene: Ncor1 Location: Chr11:62207132-62348200 bp, - strand Genetic Position: Chr11, 38.08 cM, cytoband B2
• Alliance: Ncor1^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65417
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 3 kb genomic fragment containing the coding sequences for the Sin3 interaction domain. Western blot analysis on lysates derived from MEFs of homozygous mice demonstrated that no detectable protein was produced from this allele. (J:65417)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncor1 Mutation: 394 strains or lines available

References

• Original: J:65417 Jepsen K, et al., Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000 Sep 15;102(6):753-63
• All: 3 reference(s)