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Targeted Allele Detail
Symbol: Ncor1tm1Rsd
Name: nuclear receptor co-repressor 1; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:2677822
Synonyms: N-CoR -
Gene: Ncor1  Location: Chr11:62316426-62458541 bp, - strand  Genetic Position: Chr11, 38.08 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:65417
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a 3 kb genomic fragment containing the coding sequences for the Sin3 interaction domain. Western blot analysis on lysates derived from MEFs of homozygous mice demonstrated that no detectable protein was produced from this allele. (J:65417)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncor1 Mutation:  350 strains or lines available
Original:  J:65417 Jepsen K, et al., Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000 Sep 15;102(6):753-63
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory