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Targeted Allele Detail
Symbol: Ctnna1tm1Efu
Name: catenin (cadherin associated protein), alpha 1; targeted mutation 1, Elaine Fuchs
MGI ID: MGI:2677796
Synonyms: alpha-cat fl, floxed alpha-E-catenin
Gene: Ctnna1  Location: Chr18:35118912-35254775 bp, + strand  Genetic Position: Chr18, 18.89 cM
Germline Transmission:  Earliest citation of germline transmission: J:67797
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted by homologous recombination that flanked exon 2. An adjacent floxed neomycin selection cassette was removed by Cre-mediated recombination in ES cells prior to the production of chimeric mice. (J:67797)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctnna1 Mutation:  93 strains or lines available
Original:  J:67797 Vasioukhin V, et al., Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell. 2001 Feb 23;104(4):605-17
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory