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Targeted Allele Detail
Symbol: Cdkn2atm1Nesh
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Norman E Sharpless
MGI ID: MGI:2677722
Synonyms: Arf-, P19ARF-
Gene: Cdkn2a  Location: Chr4:89274473-89294619 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Germline Transmission:  Earliest citation of germline transmission: J:88365
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA premature stop codon was generated in exon 1 beta, unique to P19ARF, by cre-mediated excision of a floxed neomycin cassette, leaving the cis-regulatory elements of both P19ARF and P16INK4 intact. Loss of P19ARF and presence of P16INK4 was confirmed by western blot analysis of homozygous mutant MEFs. (J:88365)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  52 strains or lines available
Original:  J:88365 Sharpless NE, et al., The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene. 2004 Jan 15;23(2):379-85
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory