Tg(CAG-cre/Esr1*)1Lbe
Transgene Detail

Summary

• Symbol: Tg(CAG-cre/Esr1*)1Lbe
• Name: transgene insertion 1, Corrinne Lobe
• MGI ID: MGI:2677720
• Synonyms: actin-creER, beta-actin-CreER, CAGG-CreER, CX-CreERx, pCX-CreER^TM, Tg(ACTB-cre/Esr1)1Lbe, Tg(CAG-cre/Esr1)1Lbe
• Transgene: Tg(CAG-cre/Esr1*)1Lbe Location: unknown
• Alliance: Tg(CAG-cre/Esr1*)1Lbe page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:81562
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(CAG-cre/Esr1*)1Lbe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: This transgenic construct was generated by ligating sequence encoding a fusion protein of cre recombinase and a mutant mouse estrogen receptor ligand binding domain to a CMV early enhancer and chicken beta-actin promoter. In the absence of ligand binding, the fusion protein remains in the cytoplasm. Binding of 4-hydroxytamoxifen enables the fusion protein to move to nucleus where it may act upon DNA. This transgenic line was generated by electroporating the contstruct into ES cells. Expression of the fusion protein was in a widespread mosaic pattern. Two lines were generated, BD8 with two copies of the transgene and CA6 with one copy. (J:81562)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(CAG-cre/Esr1*)1Lbe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:81562 Guo C, et al., A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis. 2002 Jan;32(1):8-18
• All: 39 reference(s)