Gabrb2^tm1.1Kwa
Targeted Allele Detail

Summary

• Symbol: Gabrb2^tm1.1Kwa
• Name: gamma-aminobutyric acid type A receptor subunit beta 2; targeted mutation 1.1, Keith A Wafford
• MGI ID: MGI:2677669
• Synonyms: beta2 N265S, Gabrb2^{tm1.1(b265S)Kwa}
• Gene: Gabrb2 Location: Chr11:42310584-42519855 bp, + strand Genetic Position: Chr11, 25.08 cM
• Alliance: Gabrb2^tm1.1Kwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85526
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A mutation was introduced into exon 8 changing the codon for asparagine at amino acid position 265 into one for serine (N265S) at the same time that a floxed neomycin resistance cassette was inserted into intron 7. The neomycin gene was subsequently removed by cre-mediated excision. This mutation does not change the expression level of this receptor subunit. (J:85526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabrb2 Mutation: 43 strains or lines available

References

• Original: J:85526 Reynolds DS, et al., Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. J Neurosci. 2003 Sep 17;23(24):8608-17
• All: 5 reference(s)