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Hba-a1tm1Led
Targeted Allele Detail
Nomenclature
Symbol: Hba-a1tm1Led
Name: hemoglobin alpha, adult chain 1; targeted mutation 1, Philip Leder
MGI ID: MGI:2677498
Synonyms: alpha1-
Gene: Hba-a1  Location: Chr11:32283511-32284465 bp, + strand  Genetic Position: Chr11, 18.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41934
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a small 295 bp fragment in the second exon of the gene. Northern blot analysis on RNA derived from homozygous embryos demonstrated that a reduced amount of alpha-globin transcript was present in comparison to wild type. The authors propose that the remaining mRNA arose from the adjacent Hba-a2 gene. (J:41934)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hba-a1 Mutation:  1 strain or line available
References
Original:  J:41934 Leder A, et al., Mouse zeta- and alpha-globin genes: Embryonic survival, alpha-thalassemia, and genetic background effects. Blood. 1997 AUG 1;90(3):1275-1282
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory