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Sall1tm1Mrau
Targeted Allele Detail
Nomenclature
Symbol: Sall1tm1Mrau
Name: sal-like 1 (Drosophila); targeted mutation 1, Michael Rauchman
MGI ID: MGI:2677452
Synonyms: sall1delta, Sall1-deltaZn, Sall1-deltaZn2-10
Gene: Sall1  Location: Chr8:89027248-89044162 bp, - strand  Genetic Position: Chr8, 43.51 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85458
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Dominant negative)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA dominant-negative allele, recapitulating the human SALL1 1277-1278delGA mutation, was generated by inserting a stop codon and a floxed neo cassette into the exon 2. The deleted region corresponded with nt 1300-3443 of the cDNA. A truncated protein was detected by Western blot analyis of homozygous mutant embryonic tissue using an N-terminal antibody. (J:85458)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sall1 Mutation:  31 strains or lines available
References
Original:  J:85458 Kiefer SM, et al., Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects. Hum Mol Genet. 2003 Sep 1;12(17):2221-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory