Tg(Th-cre)12Mrub
Transgene Detail

Summary

• Symbol: Tg(Th-cre)12Mrub
• Name: transgene insertion 12, Marcelo Rubinstein
• MGI ID: MGI:2677450
• Synonyms: TH-Cre
• Transgene: Tg(Th-cre)12Mrub Location: unknown
• Alliance: Tg(Th-cre)12Mrub page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Th-cre)12Mrub expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: Sequence encoding cre recombinase was adjpoined to 9 kb of the rat tyrosine hydroxylase (Th) promoter. The rat Th promoter sequence drove expression of cre recombinase in catecholaminergic neurons. Expression was observed in the olfactory bulb, hypothalamic and midbrain dopaminergic neurons, the locus coeruleus, amacrime neurons of the retina, chromaffin cells of the adrenal medulla, and sympathetic ganglia. (J:85520)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Th (rat) Summary of all recombinase alleles driven by Th. Comparative matrix view of recombinase activities Alliance rat Th gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:85520 Gelman DM, et al., Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neurons. Genesis. 2003 Aug;36(4):196-202
• All: 12 reference(s)