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Pecam1tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Pecam1tm1Mak
Name: platelet/endothelial cell adhesion molecule 1; targeted mutation 1, Tak W Mak
MGI ID: MGI:2677448
Synonyms: CD31-, CD31KO, PECAM-1-, PECAM-1-KO, PECAM-KO
Gene: Pecam1  Location: Chr11:106654217-106750628 bp, - strand  Genetic Position: Chr11, 69.92 cM, cytoband F3-G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53225
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 7 of the gene. No functional protein was expressed on the surface of PBLs as demonstrated by flow cytometry analysis. (J:53225)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pecam1 Mutation:  228 strains or lines available
References
Original:  J:53225 Duncan GS, et al., Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol. 1999 Mar 1;162(5):3022-30
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory