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Vpreb1tm1Shim
Targeted Allele Detail
Nomenclature
Symbol: Vpreb1tm1Shim
Name: pre-B lymphocyte gene 1; targeted mutation 1, Takeyuki Shimizu
MGI ID: MGI:2677163
Synonyms: VpreB1-
Gene: Vpreb1  Location: Chr16:16868402-16870843 bp, - strand  Genetic Position: Chr16, 10.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76947
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe entire gene together with exon 1 of Igl-5 were replaced with a neomycin resistance gene flanked by loxP sites. Lack of mRNA was demonstrated by PCR. (J:76947)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vpreb1 Mutation:  31 strains or lines available
References
Original:  J:76947 Shimizu T, et al., VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J Immunol. 2002 Jun 15;168(12):6286-93
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory