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Vil1tm1Gum
Targeted Allele Detail
Nomenclature
Symbol: Vil1tm1Gum
Name: villin 1; targeted mutation 1, Deborah L Gumucio
MGI ID: MGI:2676462
Gene: Vil1  Location: Chr1:74448543-74474719 bp, + strand  Genetic Position: Chr1, 38.54 cM, cytoband C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77460
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct containing lacZ and neo replaced 4.6 kb of genomic sequence encompassing a portion of the first coding exon (exon 1) and the following 2 exons (exons 2 and 3). An upstream non-translated exon was left intact. While low levels of aberrant transcipt were detected in mutant mice, neither normal nor truncated protein was detected by Western blot analysis. (J:77460)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vil1 Mutation:  34 strains or lines available
References
Original:  J:77460 Pinson KI, et al., Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev Dyn. 1998 Jan;211(1):109-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory