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Slc10a2tm1Pda
Targeted Allele Detail
Nomenclature
Symbol: Slc10a2tm1Pda
Name: solute carrier family 10, member 2; targeted mutation 1, Paul A Dawson
MGI ID: MGI:2676307
Synonyms: Asbt-, Slc10a2-/-
Gene: Slc10a2  Location: Chr8:5083219-5105351 bp, - strand  Genetic Position: Chr8, 2.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85312
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region of the gene extending from intron 2 through to the splice acceptor site of exon 4 was replaced with a neomycin resistance cassette. Absence of gene products was confirmed by Northern blots and by immunoblots. (J:85312)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc10a2 Mutation:  14 strains or lines available
References
Original:  J:85312 Dawson PA, et al., Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem. 2003 Sep 5;278(36):33920-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory