Pitpnatm1Vab
Targeted Allele Detail
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Symbol: |
Pitpnatm1Vab |
Name: |
phosphatidylinositol transfer protein, alpha; targeted mutation 1, Vytas A Bankaitis |
MGI ID: |
MGI:2676298 |
Synonyms: |
PITPalpha-, PITPalphadelta1::neo*, PITPalphadelta::neo* |
Gene: |
Pitpna Location: Chr11:75478923-75519630 bp, + strand Genetic Position: Chr11, 45.92 cM
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Alliance: |
Pitpnatm1Vab page
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Germline Transmission: |
Earliest citation of germline transmission:
J:85204
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Disruption caused by insertion of vector
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Mutation details: Exons 8, 9, and 10 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded residues 162 through 257 and has been shown to be essential for catalytic activity. Protein was undetected by Western blot analyses of homozygous mutant ES cells and mice.
(J:85733)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pitpna Mutation: |
37 strains or lines available
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Original: |
J:85204 Alb JG Jr, et al., Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. J Biol Chem. 2003 Aug 29;278(35):33501-18 |
All: |
7 reference(s) |
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